Future University In Egypt (FUE)
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Altagamoa Al Khames, Main centre of town, end of 90th Street
New Cairo
Faculty of Engineering & Technology
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Nada Mohamed Abd El Hamid Ali Mohamed

Basic information

Name : Nada Mohamed Abd El Hamid Ali Mohamed
Title: Assistant Lecturer
Personal Info: Nada Mohamed Abd El Hamid Ali Mohamed was born on 25/11/1989, Faculty of Engineering.


Certificate Major University Year
Masters 2019
Bachelor 2011

Researches /Publications

In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration

Nada Mohamed Abd El Hamid Ali Mohamed

Haider, M., Ibrahim, M


Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal route offers both rapid onset and evasion of first-pass metabolism. Niosomes were prepared using a combination of Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios followed by determination of entrapment efficiency, particle size and in vitro drug release. A parallel design was adopted to evaluate the pharmacokinetic performance of DTZ-loaded niosomes in male Wistar rats. Non-compartmental analysis was performed where Cmax, Tmax, t1/2, MRT, area under the release curve (AUC) and Ke were assessed. The prepared niosomes were spherical with mean particle size 0.82–1.59 μm. Span 60-cholesterol niosomes (1:1 molar ratio) showed the highest entrapment and release efficiencies. In vivo study revealed an increase in MRT, t1/2 and AUC with a decrease in Ke. In conclusion, nasal niosomal formulation of DTZ expressed suitable pharmacokinetic parameters and bioavailability through prolonged duration of action inside the body as well as low rate of elimination depicting a promising alternate to the conventional oral route.

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